Therapeutic Antibodies

Mechanisms of action of antibody

Antibodies bind to antigens and work as shown below.

Neutralizing activity

Neutralizing activity is the loss of the target's original effect.

When ligands such as growth factor bind to their receptors, ligands activate target cells and cause damages.

When therapeutic antibody binds to its target, ligand or receptor, antibody interferes ligand-receptor interaction and prevents undesirable activities.

Opsonization (Movie being prepared)

Opsonization is the facilitation of phagocytosis by phagocytes such as white blood cells and macrophages.

Cytolysis (CDC activation)

Cytolysis is the lysis of target cells by reacting complements and serum proteins.

CDC is triggered by the binding of complement to the antibody bound to cell surface an antigen.
Activated complement system lyses the target cell.
In addition, therapeutic antibody treat diseases through a variety of mechanisms.

ADCC activity

ADCC activity is cytotoxity by effector cells.

Immune cells such as macrophages and NK cells recognize the antibody bound to the target cell and destroy the target cells such as tumor cells.