Site Report

Tokyo Research Park

History

• *
  Please see the following for information on research and development.

Environmental and Safety Activities

Initiatives to Address Climate Change (Prevent Global Warming)

• Since April 2013, Tokyo Research Park has continuously investigated various energy conservation measures as a Designated Global Warming Measure Site under the Tokyo Metropolitan Environmental Security Ordinance, and has implemented global warming measures in a way that connects to real-world implementation. These efforts resulted in a significant decline in CO₂ emissions that exceeded the mandatory reductions stipulated for a Designated Global Warming Measure Site, and in 2022, we were removed as a Designated Global Warming Measure Site. As part of these activities, Tokyo Research Park offered the emissions reduced during the first and second planning periods as credits for the Carbon Offset Program for the Tokyo 2020 Games in August 2020, and cooperated in realizing Tokyo Zero Carbon 4 Days in 2020.
• As a worksite, we regularly hold Energy Conservation Measure Meeting to confirm energy monitoring and energy conservation measure results, as well as to review new measures. More recently, the Committee optimized the operational conditions and controls for air conditioner cooling and heat-source equipment, revised the conditions for laboratory air conditioners, and reviewed the use of lighting. Including efforts to address average monthly temperature fluctuations, this initiative also finely tunes the conditions as the situation requires, and produced energy-saving results.
• Tokyo Research Park has acted to introduce high-efficiency equipment with a low environmental impact for newly purchased equipment and research apparatus.

Initiatives to Prevent Air Pollution

• City gas has been used for boiler facilities thereby eliminating the emissions of SOx and dust.
• Odorous exhaust discharged during the experimentation process is cleaned with a scrubber and release into the atmosphere.

Initiatives to Prevent Water Pollution

• Recognizing water pollution prevention as a particularly important initiative, we provide employee education each year.
• With a particular focus on preventing the release of harmful substances, after collecting waste liquids containing harmful substances that exceed legal standard concentrations, we outsource disposal to a specialized waste disposal company.
• We engage in thoroughgoing wastewater treatment management by conducting regular wastewater measurements and facility inspections.

Initiatives to Reduce Waste

• We are working to avoid the use of organochlorine solvents from the research stage.
• We are working to reduce industrial waste by reusing used equipment and other devices used in research activities and diverting them as valuable resources.
• We are promoting the recycling of waste into resources by selecting waste disposal companies that can utilize material recycling and other recycling methods that have a lower environmental impact.
• We have achieved Zero emission^* status every year.

• *
  Zero emission: Kyowa Kirin Group uses the term to mean a reduction in the amount of waste disposed in landfills to no more than 0.1% of generated waste.

Compliance with the PRTR Act

• PRTR substances (including Class I Designated Chemical Substances) are properly managed, and the emissions of PRTR substances in 2022 were at a level that does not require reporting to the government.

Other Initiatives

• In order to strengthen environmental awareness among all employees, we actively provide regular environmental education, request explanations on and support for energy conservation activity results, and conduct visits to environment-related facilities at each worksite.
• As clean-up activities in the surrounding area, we conduct clean-up efforts at the nearby Machida Chuo Park, and participate in the Sakai River clean-up activity organized by an outside organization. We have also expanded the scope of our efforts to give back to the community by creating flower beds using part of the grounds.
• In 2025, we registered as a Machida Eco Declaration Office and have been sharing our various environmental activities with the local community to help achieve a sustainable society.

Fuji Site (Fuji Research Park and CMC R&D Center)

History

• *
  Please see the following for information on research and development, production, and quality assurance.

Environmental and Safety Activities

Initiatives to Address Climate Change (Prevent Global Warming)

• We have been purchasing RE100^*-compliant power since January 1, 2022, and have switched over all electricity used to renewable energy.
• We installed solar power generation facilities, which are used to supply electricity.
• Since 2019, we have established the Energy Management Subcommittee to monitor energy consumption and explore energy-saving measures.
• When upgrading equipment, we adopt high-efficiency models while also optimizing the operating conditions and schedules of large-scale air conditioning systems and converting lighting to LED, with the aim of further improving energy efficiency.

• *
  Our Group is taking actions in line with Kirin Holdings’ “Kirin Group Environmental Vision 2050,” but our Group alone has not joined RE100.

Initiatives to Prevent Air Pollution

• We use city gas, which emits no sulfur oxides, as the fuel for small boilers.
• We are working to reduce the amount of city gas used by updating to high-efficiency boilers.

Initiatives to Prevent Water Pollution

• We conduct annual emergency response drills in preparation for potential wastewater issues and review our emergency response procedures as necessary. In addition, we have been providing employee training on wastewater management since 2020.
• The Energy Management Subcommittee is also working to conserve water resources by monitoring water intake volumes and implementing water-saving measures.
• To ensure thorough wastewater treatment management, regular wastewater measurements and facility inspections are conducted.

Initiatives to Reduce Waste

• Having positioned waste as an important environmental issue, we have provided waste-related education to employees since 2021.
• We are working to reduce the amount of waste, and we are also promoting recycling through thorough sorting, etc., and have achieved zero emissions^*. In addition, we are working to improve the resource recycling rate of waste plastic by thoroughly sorting waste plastic and beginning to transport it to intermediate treatment companies that can process it for material recycling.

• *
  Zero emission: Kyowa Kirin Group uses the term to mean a reduction in the amount of waste disposed in landfills to no more than 0.1% of generated waste.

Compliance with the PRTR Act

• In 2025, there were no regulated substances whose handling volumes exceeded the reporting thresholds set forth in the PRTR Act. We will continue to monitor and manage the usage and emissions of these substances and strive to reduce our environmental impact.

Other Initiatives

• Through activities such as the “Cleanup around Ayutsubo Waterfall,” the “River Friendship Kise River Cleanup,” and the “Release of Young Amago Trout,” we work alongside local residents to protect our local natural environment. We also conduct cleanup efforts around our facilities to promote community-based environmental conservation.

• We regularly conduct environmental patrols within and around the grounds.
• We promote green purchasing by pursuing the use of environmentally-friendly products.

• Not applicable

Takasaki Plant (including Bio Process Research and Development Laboratories)

History

1. *1:
   News Release : Kyowa Kirin Completed Construction of a Multipurpose Facility Relating to Quality Assurance (Q-TOWER) at Takasaki Plant
2. *2:
   GMP : Good Manufacturing Practice : A summary of the requirements for meeting established quality standards in the manufacture of pharmaceutical products and for proper control of the manufacturing process of such products.
3. *3:
   News Release : Kyowa Kirin Completed Construction of a New Biopharmaceutical DS Manufacturing Facility at Takasaki Plant -Acceleration of development through the establishment of an innovative global manufacturing structure-

• *
  Please see the following for information on research and development.

Environmental and Safety Activities

Initiatives to Address Climate Change (Prevent Global Warming)

• Under the leadership of the Energy Conservation Liaison Meeting, Takasaki Plant has updated equipment and reviewed equipment use and management in an effort to reduce energy usage.
• We installed solar power generation facilities on the premises, which are used to supply electricity. In addition, we have installed a large-scale solar power generation system in the new building, dramatically increasing our power generation capacity.
• We have undertaken activities to improve awareness of energy conservation. This includes awarding employees for their initiatives to reduce energy.
• We regularly inspect chlorofluorocarbon gas charging equipment in an effort to prevent leaks.
• Since January 2020, we have switched over 75% of the electricity used by the Takasaki Plant with RE100^*1-compliant electricity that emits no CO₂. Since January 2023, we have expanded and introduced RE100-compliant power for all electricity used at the Takasaki Plant^*2.

• *1:
  Our Group is taking actions in line with Kirin Holdings’ “Kirin Group Environmental Vision 2050,” but our Group alone has not joined RE100.
• *2:
  News Release:
  Kyowa Kirin Has Introduced RE100 Renewable Electricity to All Purchased Electricity at Its Two Plants and Three Laboratories

Initiatives to Prevent Air Pollution

• emit any SOx or dust. Moreover, we regularly update and inspect boilers to further curb environmental impacts, and to use steam more efficiently.

Initiatives to Prevent Water Pollution

• Along with expanding manufacturing equipment, Takasaki Plant installed additional wastewater treatment facilities and introduced membrane treatment equipment in 2009, 2016, and 2022, thereby enhancing its ability to treat wastewater, which has a high load variability.
• We implement thorough wastewater treatment management by conducting regular wastewater measurements and facility inspections.
• Having positioned water pollution as an important environmental issue, we provide regular education to our employees.

Initiatives to Reduce Waste

• By reducing and recycling industrial waste, Takasaki Plant has continued to achieve Zero emission^* status.
• To achieve our waste plastic recycling targets, we are encouraging all employees to sort waste plastic properly when disposing of it.

• *
  Zero emission: Kyowa Kirin Group uses the term to mean a reduction in the amount of waste disposed in landfills to no more than 0.1% of generated waste.

Compliance with the PRTR Act

• Although Takasaki Plant uses PRTR Act-designated Class 1 Chemical Substances, the amounts fall below those requiring reporting to the government.

Other Initiatives

• With the goal of strengthening environmental awareness among employees and of fully eliminating environmental accidents, Takasaki Plant provides detailed environmental education. Moreover, it engages in environmentally-friendly construction work.

• *
  News Release : Kyowa Kirin's Takasaki Plant received the 2024 Minister of the Environment Award (Contribution to Regional Environmental Conservation)

Ube Plant

History

• *
  Please see the following for information on production at the Ube Plant. (in Japanese only)

Environmental and Safety Activities

Initiatives to Address Climate Change (Prevent Global Warming)

• We introduced a solar power generation facility based on the PPA method on March 1, 2023, which has begun supplying electricity to each plant building and to the new office building. In addition, on April 1, 2023, we switched over all purchased electricity to RE100^*1-compliant renewable energy^*2.
• The SF building achieved net-zero primary energy consumption (derived from fossil fuels) and received the highest rank of "ZEB" certification (the third case in Yamaguchi Prefecture)^*3.
• Given the risk of storm surges associated with extreme weather events and rising sea levels, the main facilities and site are surrounded by a tidal embankment to ensure the safety of employees and a stable supply of pharmaceutical products.
• We have acted to introduce high-efficiency equipment with a low environmental impact for newly installed and updated equipment.

• *1:
  Our Group is taking actions in line with Kirin Holdings’ “Kirin Group Environmental Vision 2050,” but our Group alone has not joined RE100.
• *2:
  News Release: Kyowa Kirin Has Introduced RE100 Renewable Electricity to All Purchased Electricity at Its Two Plants and Three Laboratories
• *3:
  News Release: Kyowa Kirin Completed Construction of a New Office Building at Ube Plant

Initiatives to Prevent Air Pollution

• Ube Plant is acting to prevent air pollution by introducing kerosene boilers that do not emit any sulfur oxides.

Initiatives to Prevent Water Pollution

• Along with separating and treating waste liquids that have a high environmental impact as industrial waste, Ube Plant installed sensors (TOC, pH, temperature) along wastewater channels as part of a system that collects waste liquid and prevents it from escaping to the outside in the event of an irregularity. We also act to prevent water pollution of public waters by conducting training and education that assumes the occurrence of an irregularity.
• Rainwater discharged from the Ube Plant site into rivers is collected in a rainwater drainage tank, and the quality of the rainwater drainage is continuously monitored using pH meters and oil film meters.
  When an irregularity is detected, a movable gate within the rainwater drainage system operates to switch the drainage channel and collect the rainwater in an emergency inflow tank as a means of preventing the risk of irregular rainwater from being discharged to rivers (environmental accident).

Initiatives to Reduce Waste

• By recycling industrial waste, Ube Plant has continued to achieve Zero emission^* status since FY2004.

• *
  Zero emission: Kyowa Kirin Group uses the term to mean a reduction in the amount of waste disposed in landfills to no more than 0.1% of generated waste.

Compliance with the PRTR Act

• Although Ube Plant uses PRTR Act-designated Class 1 Chemical Substances, the amounts fall below those requiring reporting to the government.

Other Initiatives

• In order to foster and maintain its water sources, Ube Plant conducts forest thinning, pruning, weeding, and other activities in the vincinity of Akiyoshidai. It also actively engages in clean-up activities in nearby communities, and conducts beautification and clean-up activities in the area around the plant each month. In recent years, at the request of Ube City, we have been participating in and carrying out maintenance work for the conservation of the satoyama biotope owned by the city.

• We regularly provide environmental education for all plant employees in order to promote a greater awareness of the environment.
• We participate in community volunteer activities and conduct SDGs campaigns within the plant as needed.